Investigation of Auger Electron Emitting Radionuclides Effects in Therapy Using the Geant4-DNA Toolkit: A Simulation Study

Microdosimetry study of a multicellular model with mono-energetic electrons using Geant4-DNA simulation toolkit

Introduction: The goal of any type of radiation therapy in the treatment of tumors, in addition to destroying cancer cells, is to minimizing radiation to nearby healthy cells and thus reducing side damages. For this purpose, targeted radiation therapy (TRT) is more effective in treating of single cells or small cluster of cells. The main factor in the success of this method is...

Dosimetry of Auger-Electron-Emitting Radionuclides

Investigation of the direct DNA damages irradiated by protons of different energies using geant4-DNA toolkit

Background: The total yields of direct Single-Strand Breaks (SSBs) and Double-Strand Breaks (DSBs) in proton energies varying from 0.1 to 40 MeV were calculated. While other studies in this field have not used protons with energy less than 0.5 MeV, our results show interesting and complicated behavior of these protons. Materials and Methods: The simulation has been done using the Geant4-DNA too...

Comparing water to DNA for simulation of Auger electron direct damage to DNA using Geant4

Typically water is used as an analog material for Deoxyribonucleic Acid (DNA) in Monte Carlo simulations of biological radiation interactions. Prior to this work, it was unclear whether water is an appropriate stand-in for DNA when simulating direct radiation damage on the nano scale. The increased interest in targeted tumor therapy using Auger electrons has requires an understand of the radiob...

Monte Carlo evaluation of Auger electron-emitting theragnostic radionuclides